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Mitochondrial dysfunction happens in PD characterized by decreased exercise of mitochondrial advanced I and elevated reactive oxygen species production [forty two]. In vitroStill, plainly rasagiline is clinically successful in adjunct to DA therapy for early/stable PD, but safinamide is ineffective as an adjunct to DA. Both rasagiline and safinamid

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Below usual circumstances, bilirubin diglucuronide could be the predominant molecule synthesized. However, When the conjugation process is confused beneath disorders of abnormal bilirubin synthesis, most bilirubin could possibly be conjugated as bilirubin monoglucuronide. The ratio of mono-conjugated towards the dis-conjugated pigment in bile is 1:

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